Help with building a deck that supports this combo

[blueberry314]

Biomancer's Familiar + Zacama, Primal Calamity + Wilderness Reclamation

This seems pretty fun as an alternate wincon but how would this work in Standard? Modern?

Would this work well in Kynaios and Tiro of Meletis EDH?

[Judaspriester]

First of all you could replace Biomancer's Familiar with Training Grounds. Same effect, but cheaper (mana wise) and harder to removal. But this would kick you out of Standart.
For Multiplayer (like EDH) i would replace Wilderness Reclamation with Seedborn Muse (or play both). The Muse allows you to entap together with every opponent, which speeds up the idea a little.

If you want to cut it down colorwise, you could also replace Zacama with Memnarch and try to steal the whole table in stead of removing everything. This way you just need Simic.

[ORCH1D]

From a modern perspective, the problem is that Zacama, Primal Calamity is way too expensive, and Wilderness Reclamation doesn't help you ramp into it. You get to untap all of your lands on your endstep, which allows you to keep up mana for the opponents turn, but if you try to tap them for mana you just lose that mana as the phases pass to your turn. This means you need a way of keeping that mana.

Kruphix, God of Horizons is the first way that springs to mind to make this work, as this with Wilderness Reclamation effectively doubles your land mana, which means you can get to Zacama mana the turn after you drop the combo. The problem, as with all combo decks, is balancing finding the combo (cards like serum visions), making sure all pieces of the combo resolve (cards like mana leak) and speeding up to the combo to the point you don't die to burn before it goes off (cards like birds of paradise).

Biomancer's Familiar does work well with Zacama, and with the mana generating engine you have you could probably kill the turn it drops with Zacama's three damage ability, which is good payoff, but as Judaspriester pointed out it is strictly worse than Training Grounds in this deck (not only cheaper, but also doesn't die to removal).

Hopefully that was useful, sorry for the long post