I think infect is good in edh if there's an aspect of control to it and backup plans. I use Ishai and reyhan, and play on low curve cmc creatures with infect, especially those with evasion. Using totems and other means of indestructible protection, I can use board wipes to reassign counters however I want in favorable positions with low cmc counters to protect my decisions. I've been nearly undefeated with it. I have options of also just doing volition and board control as as well. If you're playing with more than 4 players, which has always been a disaster cause then combo players either win at some point or die on turn 1, infect and voltron will fall flat on their face. If done properly with enough speed, I feel it can win pretty handely.