My regular playgroup has 4 to 6 players playing casual, 60-card constructed multiplayer. If it was printed, it is legal (no one has lowered themselves to silver borders...yet); if anything gets oppressively annoying we police each other for the most part.
We find that unless rules are added to speed up the game, we only play one a night; so we alternate from night to night with one of:
Near-sighted - you can only attack or target the player or creatures directly to your right or left; global effects and wipes act normally.
Right-Left switch - a coaster with 'L' for left on one side and 'R' on the flip side for right. On your turn, you may only attack or target the player closest to you on the appropriate side, left or right. If you attack, the coaster is flipped. don't attack with creatures, the coaster does not flip.
Perma-Monarchy - first player to do combat damage to another player is the monarch, no card with the Monarchy mechanic needed. Then normal Monarchy rules to encourage attacks.
For infect, I like to replace 'infect' with 'wither'. There are some infect cards that are still fun without the infect part.