So your saying if you have hexproof players cant play cards that exile your entire graveyard or they can?
It depends on the wording. Look at
Relic of Progenitus. It's first ability targets a player. So if you (the player) have hexproof, that ability can't be used to
exile cards from your graveyard. The second ability doesn't target a player, so it can still be used to
exile your graveyard, even if you have hexproof.