For what purpose?
The primary point of having wipes is to wipe stuff. Therefore the biggest factor is reliability.
Toxic Deluge is one of the most reliable wipes since it kills indestructible things, and for only 3 mana (of course the cost is that it struggles with very large things and/or when you’re at low health).
There is, I think, a lot of space for “value wipes”.
Consider Citywide Burst,
Retribution of the Meek,
Winds of Rath, or indeed
Harsh Mercy. These are just things that typically, when you’re running them, hit others more than they hit you. Those seem like good ways just to set other people back. However, I would be loathe
only to run such cards as wipes; they don’t fill the same role.