Dimirilirium Denial (Standard)

Lost legacy can hit your own Eternal Scourge to pull it out early, Harsh Scrutiny lets us deny them early creatures and helps us learn what to get rid of from them asap, as does vessel of malignity. Pick the brain works good early as an anything goes scrutiny, and later to thin their deck. You wanna hit delirium pretty early - sac a Metalspinner's Puzzleknot, a Vessel of Malignity, an Evolving Wilds, and let one of your curious homunculus eat removal or sac an eternal scourge to an emerger and you're lookin good. Fastest Route to Delirium:
T1: Evolving Wilds for an Island
T2: Play a Swamp, Harsh Scrutiny, counter a sorcery on their turn with Invasive Surgery
T3: Vessel of Malignity, if you haven't countered a spell with Dispel or Invasive yet, do that
T4: Sac Vessel of Malignity and you're there.

Alternate:
T1: Evolving Wilds for Island
T2: Swamp, Curious Homunculus
T3: Swamp, Collective Brutality, Discarding an Eternal Scourge (Modes 1 and 3) and a Metalspinner's Puzzleknot if they have a Creature out. (Alternatively, Discarding the puzzleknot for modes 1&2 and killing your own homunculus.) Play Vessel of Malignity
T4: Island, Sac Vessel of Malignity(not if you killed your Homunculus obviously, you won't have the mana for pick the brain that way), Pick the Brain with delirium active.

Win game by beating with big prowess guys and emerged assholes.