The 13th House (EDH / Commander)

A combination of constellation and infect, led by the perfect commander for such a thing - Pharika, Goddess of Affliction. Essentially, she's a sickness/healing/death/rebirth goddess. And both constellation and infect suit her very well. I am rather fond of the idea that Pharika would wield a dread disease only she can heal, by the use of Melira.

The name of the 13th House is strategic. There is no 13th house. Astrology stops at 12. But there is a 13th card in the tarot, Death. Quite apt, in my eyes.

Use my totem armors and best enchantments on Pharika so that she will always have enough devotion, while keeping my enemies at bay behind a wall of mostly infect creatures. Then I can either swoop in en masse for the kill, using the infect creatures, or use my own graveyard create an endless army of snake enchantments, thus fulfilling the backup win condition of Epic Struggle. Or, I could win by lifegain through Defiant Bloodlord. Have you ever heard of death by Blunt the Assault before?

But all of this is meant to distract you from the true win strategy, Pharika's assistant and Kylie's only other planeswalker friend, Vraska the Unseen.